Zheng et al. Cryo-electron tomography reconstructs polymer in liquid film for fab-compatible lithography, Nature Communications, September 30, 2025
Understanding protein structures at the molecular level is of paramount importance in contemporary biomedicine.1 The correlation between variations in protein structures and their biological functions is vital to life processes and intricately linked to the emergence of numerous diseases.2 Revealing the three-dimensional structures of proteins can assist the fundamental research for biology as well as for design of precision therapeutics, a field known as ‘structure-based therapeutics’.3 This research approach facilitates the identification of effective targets4 and enables the creation of drugs that specifically target individual proteins. An in-depth understanding of protein structures also provides deeper insights into disease mechanisms, fostering innovation in the development of novel vaccines and diagnostic tools. It serves as new pathways for the discovery of biomarkers, which can lead to earlier disease diagnosis and more effective clinical interventions.