Author Archives: admin

You et al. In situ structure of the red algal phycobilisome-PSII-PSI-LHC megacomplex. Nature, April, 2023 In oxygenic photosynthetic organisms, light energy is captured by antenna systems and transferred to photosystem II (PSII) and photosystem I (PSI) to drive photosynthesis1,2. The … Continue reading →

Zheng et al. Uniform thin ice on ultraflat graphene for high-resolution cryo-EM. Nature Methods, January, 2023 Cryo-electron microscopy (cryo-EM) visualizes the atomic structure of macromolecules that are embedded in vitrified thin ice at their close-to-native state. However, the homogeneity of ice thickness, … Continue reading →

Lu et al. Functionalized graphene grids with various charges for single-particle cryo-EM, Nature Communications, November 7, 2022 A major hurdle for single particle cryo-EM in structural determination lies in the specimen preparation impaired by the air-water interface (AWI) and preferential particle-orientation problems. … Continue reading →

Su et al. Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD, Nature, July, 2022 Small interfering RNAs (siRNAs) are the key components for RNA interference (RNAi), a conserved RNA-silencing mechanism in many eukaryotes1,2. In Drosophila, an RNase III enzyme Dicer-2 (Dcr-2), aided … Continue reading →

Xu et al. Structural engineering of graphene for high-resolution cryo-electron microscopy, SmartMat., May 26, 2021 The revolutionary improvement of hardware and algorithm in cryogenic electron microscopy (cryo‐EM) has made it a routine method to obtain structures of macromolecules at near‐atomic … Continue reading →

Niu et al. Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin, EMBO J.，June, 2021 Pangolins have been suggested as potential reservoir of zoonotic viruses, including SARS-CoV-2 causing the global COVID-19 outbreak. Here, we study the binding … Continue reading →

Liu et al. Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM. Biophysics Reports, July, 2021 Although single-particle cryogenic electron microscopy (cryo-EM) has been applied extensively for elucidating many crucial biological mechanisms at the molecular level, this technique still … Continue reading →

Nie et al. Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants. Cell Discov., July 20, 2021 Coronavirus disease 2019 (COVID-19), a pandemic disease caused by the newly emerging severe acute respiratory syndrome … Continue reading →

Liu et al. Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Research, Epub 2020 Oct 6. Group II introns are the putative progenitors of nuclear spliceosomal introns and use the same two-step … Continue reading →

On July 1, 2020, Nan Liu (2020 Ph.D. Graduate) was awarded the honorary title of Outstanding Graduate of Beijing.