Liu T, Dai A, Cao Y, Zhang R, Dong MQ, Wang HW*. (2017) Structural Insights of WHAMM’s Interaction with Microtubules by Cryo-EM. J. Mol. Biol., 429:1352-1363

Xu J, Zhao L, Xu Y, Zhao W, Sung P*, Wang HW*. (2017) Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange. Nat. Struct. Mol. Biol., 24:40-46

Wang HW*, Wang JW. (2017) How cryo-electron microscopy and X-ray crystallography complement each other. Protein Sci., 26:32-39 (Review)

Wang HW*, Lei J*, Shi Y*. (2017) Biological cryo-electron microscopy in China. Protein Sci., 26:16-31 (Review)


Yang H, Wang J, Liu M, Chen X, Huang M, Tan D, Dong MQ, Wong CC, Wang J*, Xu Y*, Wang HW*. (2016) 4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1. Protein Cell, 7:878-887

Agrawal RK*, Wang HW*, Belfort M*. (2016) Forks in the tracks: Group II introns, spliceosomes, telomeres and beyond. RNA Biol., 13:1218-1222

Gong X, Qian H, Shao W, Li J, Wu J, Liu JJ, Li W, Wang HW, Espenshade P*, Yan N*. (2016) Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Research, 26:1197-1211

Liu JJ, Niu CY, Wu Y, Tan D, Wang Y, Ye MD, Liu Y, Zhao W, Zhou K, Liu QS, Dai J, Yang X, Dong MQ, Huang N, Wang HW*. (2016) CryoEM structure of yeast cytoplasmic exosome complex. Cell Research, 26:822-837

Qu G, Kaushal PS, Wang J, Shigematsu H, Piazza CL, Agrawal RK*, elfort M*, Wang HW*. (2016) Structure of a group II intron in complex with its reverse transcriptase. Nat. Struct. Mol. Biol., 23:549-557

Wang J*, Chai J, Wang HW. (2015) Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA. FEBS J., 283:1631-1635

Tan D, Li Q, Zhang MJ, Liu C, Ma C, Zhang P, Ding YH, Fan SB, Tao L, Yang B, Li X, Ma S, Liu J, Feng B, Liu X, Wang HW, He SM, Gao N, Ye K, Dong MQ*, Lei X* (2016) Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Elife, pii: e12509

Qin S, Yin H, Yang C, Dou Y, Liu Z, Zhang P, Yu H, Huang Y, Feng J, Hao J, Hao J, Deng L, Yan X, Dong X, Zhao Z, Jiang T, Wang HW, Luo SJ, Xie C*. (2016) A magnetic protein biocompass. Nat Mater., 15:217-226

Jia N, Liu N, Cheng W, Jiang YL, Sun H, Chen LL, Peng J, Zhang Y1, Ding YH, Zhang ZH, Wang X, Cai G, Wang J, Dong MQ, Zhang Z, Wu H, Wang HW*, Chen Y*, Zhou CZ*. (2016) Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO Reports, 17:235-248


Wang J, Wang W, Song W, Han Z, Zhang H, Chai J*, Wang HW*, Wang J*. (2015) An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy data. Protein Cell, 6:919-923 (Letter)

Wang HW*. (2015) Opening new doors for understanding eukaryotic RNA splicing. Sci China Life Sci., 58:1171-1172 (Editorial Material)

Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF*, Chai J*. (2015) Structural and biochemical basis for induced self-propagation of NLRC4. Science, 350:399-404

Tomko RJ Jr*, Taylor DW, Chen ZA, Wang HW, Rappsilber J, Hochstrasser M*. (2015) A single α helix drives extensive remodeling of the proteasome lid and completion of regulatory particle assembly. Cell, 163:432-444

Song W, Wang J, Han Z, Zhang Y, Zhang H, Wang W, Chang J, Xia B, Fan S, Zhang D, Wang J*Wang HW*, Chai J*. (2015) Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13Nat. Struct. Mol. Biol., 22:782-787

Chang HY, Liao CY, Su GC, Lin SW, Wang HW, Chi P. (2015) Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1J. Biol. Chem., 290:19863-19873

Tagare HD, Kucukelbir A, Sigworth FJ, Wang HW, Rao M. (2015) Directly reconstructing principal components of heterogeneous particles from cryo-EM imagesJ. Struct. Biol., 191:245-262

Wang HW*. (2015) Cryo-electron microscopy for structural biology: current status and future perspectivesSci. China Life Sci., 58:750-756 (Review)

Zhou Q, Huang X, Sun S, Li X, Wang HW*, Sui SF*. (2015) Cryo-EM structure of SNAP-SNARE assembly in 20S particleCell Research, 25:551-560

Chang S, Sun D, Liang H, Wang J, Li J, Guo L, Wang X, Guan C, Boruah BM, Yuan L, Feng F, Yang M, Wang L, Wang Y, Wojdyla J, Li L, Wang J, Wang M, Cheng G, Wang HW*Liu Y*. (2015) Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution. Mol Cell, 57:925-935

Liu Z, Wang J, Li G*, Wang HW*. (2015) Structure of precursor microRNA’s terminal loop regulates human Dicer’s dicing activity by switching DExH/D domain. Protein Cell, 6:185-193


Liu JJ, Bratkowski MA, Liu X, Niu CY, Ke A*, Wang HW*. (2014) Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM. Nat. Struct. Mol. Biol., 21:95-102

Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, Chi P, Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P*. (2014) Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Nucleic Acids Res., 42:906-917


Yin P, Li Q, Yan C, Liu Y, Liu J, Yu F, Wang Z, Long J, He J, Wang HW, Wang J, Zhu JK, Shi Y, Yan N*. (2013) Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature, 504:168-171

Wolin SL*, Belair C, Boccitto M, Chen X, Sim S, Taylor DW, Wang HW. (2013) Non-coding Y RNAs as tethers and gates: Insights from bacteria. RNA Biol., 10:1602-1608

Busygina V, Gaines WA, Xu Y, Kwon Y, Williams GJ, Lin SW, Chang HY, ChiP, Wang HW, SungP. (2013) Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1. DNA Repair., 12:707-712

Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC, Wang HW, and Ye S*. (2013) FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation. Science, 341:392-395

Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA*, Wang HW*. (2013) Substrate-specific structural rearrangements of human Dicer. Nat. Struct. Mol. Biol., 20:662-670

Chen X, Taylor DW Fowler CC, Button JA, Galan JE, Wang HW, Wolin SL*. (2013) Identification of an RNA degradation machine sculpted by Ro autoantigen and noncoding RNA. Cell, 153:166-177


Li B, Li N, Wang F, Guo L, Huang Y, Liu X, Wei T, Zhu D, Liu C, Pan H, Xu S, Wang HW, Gu L*. (2012) Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motilityNucleic Acids Res., 40:11073-11085

Shen QT, Hsiue PP, Sindelar CV, Welch MD, Campellone KG*, Wang HW*. (2012) Structural insight into WHAMM-mediated cytoskeletal coordination during membrane remodelingJ. Cell Biol., 199:111-124 (Cover)

Nam KH, Haitjema C, Liu X, Ding F, Wang HW, DeLisa MP*, Ke A*. (2012) Cas5d protein processes pre-crRNA and assemblies into a Cascade-like interference complex in subtype I-C/Dvulg CRISPR-Cas systemStructure, 20:1574-1584

Bower-Phipps KR, Taylor DW, Wang HW, Baserga SJ*. (2012) The box C/D sRNP dimeric architecture is conserved across domain Archaea. One to fuse and three to keep the nascent fusion pore open. RNA, 18:1527-1540

Shi L, Shen QT, Kiel A, Wang J, Wang HW, Melia TJ, Rothman JE*, Pincet F*.  (2012) SNARE Proteins: one to fuse and three to keep the nascent fusion pore openScience, 335:1355-1359

Chang LF, Chen S, Liu CC, Pan XJ, Jian JS, Bai XC, Xie X, Wang HW, Sui SF*. (2012) Structural characterization of full-length NSF and 20 S particlesNature Struct. Mol. Biol., 19:268-275

Zhou K, Kanai R, Lee P, Wang HW*, Modis Y*. (2012) Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin. J. Struct. Biol., 177:402-409

Before 2012

Chandramouli P, Hernandez-Lopez R, Wang HW, Leschziner AE*. (2011) Validation of the orthogonal tilt reconstruction method with a biological test sampleJ. Struct. Biol., 175:85-96

Liu XQ, Wang HW*. (2011) Single particle electron microscopy reconstruction of the exosome complex using the random conical tilt methodJ. Vis. Exp., doi: 10.3791/2574

Ramey VH, Wang HW, Nakajima Y, Wong A, Liu J, Drubin D, Barnes G, Nogales E*. (2011) The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubuleMol. Biol. Cell, 22:457-466

Wu X, Shen QT, Stokes N, Lu C, Zheng Q, Polak L, Wang HW, Fuchs E*. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3βCell, 144:341-352

Yang H, Wang J, Jia X, McNatt M, Zang T, Pan B, Meng W, Wang HW, Bieniasz P, Xiong Y*. (2010) Structural insight into the mechanisms of enveloped virus tethering by TetherinProc. Natl. Acad. Sci. USA, 107:18428-18432

Nogales E*, Ramey VH, Wang HW. (2010) Cryo-EM studies of structural intermediates in microtubule dynamic instability and interaction of microtubules with kinetochore complexesMethods Cell Biol., 95:129-156 (Review; Book Chapter)

Wang HW*, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna JA*, Nogales E*. (2009) Structural basis for RNA processing by the human RISC-loading complexNat. Struct. Mol. Biol., 16:1148-1153

Wu Z, Wang HW, Mu W, Quyang Z, Nogales E, Xing J*. (2009) Simulations of tubulin sheet polymers as possible structural intermediates in microtubule assembly. PLoS One, 4:e7291

Ramey VH, Wang HW, Nogales E* (2009) Ab initio reconstruction of helical samples with heterogeneity, disorder and coexisting symmetriesJ. Struct. Biol., 167:97-105

Shen QT, Bai XC, Chang LF, Wu Y, Wang HW, Sui SF* (2009) Bowl-shaped oligomeric structures on membranes as DegP’s new functional forms in protein quality controlProc. Natl. Acad. Sci. USA, 106:4858-4863

Wang HW, Long S, Ciferri C, Westermann S, Drubin DG, Barnes G, Nogales E*. (2008) Architecture and flexibility of the yeast Ndc80 kinetochore complexJ. Mol. Biol., 383:894-903

Wang HW*, Wang J, Ding F, Callahan K, Bratkowski MA, Bulter JS, Nogales E, Ke A*. (2007) Architecture of the yeast Rrp44-exosome complex suggests routes of RNA recruitment for 3’-end processingProc. Natl. Acad. Sci. USA, 104:16844-16849

Wang HW, Ramey VH, Westermann S, Leschziner AE, Welburn JPI, Nakajima Y, Drubin DG, Barnes G, Nogales E*. (2007) Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanismsNat. Struct. Mol. Biol., 14:721-726

Nogales E*, Wang HW. (2006) Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relativesCurr. Opin. Struct. Biol., 16:221-229 (Review)

Nogales E*, Wang HW. (2006) Structural intermediates in microtubule assembly and disassembly: how and why? Curr. Opin. Cell Biol., 18:179-284 (Review)

Westermann S, Wang HW, Avila-Sakar A, Drubin DG, Nogales E, Barnes G*. (2006) The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule endsNature, 440:565-563

Wang HW*, Long S, Finley KR, Nogales E. (2005) Assembly of GMPCPP-bound tubulin into helical ribbons and tubes and effect of colchicineCell Cycle, 4:1157-1160

Wang HW, Nogales E*. (2005) Nucleotide-dependent bending flexibility of tubulin regulates microtubule assemblyNature, 435:911-915

Westermann S, Avila-Sakar A, Wang HW, Niederstrasser H, Wong J, Drubin DG, Nogales E, Barnes G*. (2005) Formation of a dynamic kinetochore-microtubule interface through assembly of the Dam1 ring complexMol. Cell, 17:277-290

Wang HW, Nogales E*. (2005) An iterative Fourier-Bessel algorithm for reconstruction of helical structures with severe Bessel overlapJ. Struct. Biol., 149:65-78 (Cover)

 Chen Y, Lu YJ, Wang HW, Yuan S, Chang Z, Sui SF*. (2003) Two-dimensional crystallization of a small heat shock protein HSP16.3 on lipid layerBiochem. Biophysic. Res. Commun., 310:360-366

Wu Y, Wang HW, Ji SR, Sui SF*. (2003) Two-dimensional crystallization of rabbit C-reactive protein monomeric subunitsActa. Crystallogr. D. Biol. Crystallogr.,59:922-926

Nogales E*, Wang HW, Niederstrasser H. (2003) Tubulin rings: which way do they curve?Curr. Opin. Struct. Biol., 13:256-261 (Review)

Wang HW, Chen Y, Yang H, Chen X, Duan MX, Tai PC*, Sui SF*. (2003) Ring-like pore structures of SecA: implication for bacteria protein-conducting channelsProc. Natl. Acad. Sci. USA, 100:4221-4226

Wu Y, Ji SR, Wang HW, Sui SF*. (2002) Study of the spontaneous dissociation of rabbit C-reactive proteinBiochemistry (Mosc.), 67:1377-1382

Wang HW, Wu Y, Chen Y, Sui SF*. (2002) Polymorphism of structural forms of C-reactive proteinInt. J. Mol. Med., 9:665-671

Wang HW, Sui SF*. (2001) Dissociation and subunit rearrangement of membrane-bound human C-reactive proteinBiochem. Biophysic. Res. Commun., 288:75-79

Wang HW, Sui SF*. (2001) Two-dimensional assembly of pentameric C-reactive proteins on lipid monolayersJ. Struct. Biol., 134:46-55

Wang HW, Lu YJ, Li LJ, Liu S, Wang DN, Sui SF*. (2000) Trimeric ring-like structure of ArsA ATPaseFEBS Lett., 496:105-110

Zhou H, Wang HW, Zhu K, Sui SF, Xu P, Yang SF, Li N*. (1999) The multiple roles of conserved arginine 286 of 1-aminocyclopropane-1-carboxylate synthase. Coenzyme binding, substrate binding, and beyond. Plant Physiol., 121:913-919

Wang HW, Sui SF*. (1999) Pentameric two-dimensional crystallization of rabbit C-reactive protein on lipid monolayersJ. Struct. Biol., 127:283-286

Mi LZ, Wang HW, Sui SF*. (1997) Interaction of Rabbit C-Reactive Protein with Phospholipid Monolayers Studied by Micro- fluorescence Film Balance with an Externally Applied Electric FieldBiophys. J., 73:446-451