The microtubule (MT) and actin cytoskeletons drive many essential cellular processes, yet fairly little is known about how their functions are coordinated. One factor that mediates important cross talk between these two systems is WHAMM, a Golgi-associated protein that utilizes MT binding and actin nucleation activities to promote membrane tubulation during intracellular transport. Using cryoelectron microscopy and other biophysical and biochemical approaches, we unveil the underlying mechanisms for how these activities are coordinated.
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- Zheng et al. Self-assembled superstructure alleviates air-water interface effect in cryo-EM, Nature Communications, 2024
- Yang et al. Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects, Nature Methods, 2024
- Xu et al. Graphene sandwich-based biological specimen preparation for cryo-EM analysis, PNAS, 2024
- Zhou et al. Structural insights into the mechanism of GTP initiation of microtubule assembly, Nature Communications, 2024
- You et al. In situ structure of the red algal phycobilisome-PSII-PSI-LHC megacomplex, Nature, April, 2023